Rabgef1^tm1Glli
Targeted Allele Detail

Summary

• Symbol: Rabgef1^tm1Glli
• Name: RAB guanine nucleotide exchange factor (GEF) 1; targeted mutation 1, Stephen J Galli
• MGI ID: MGI:3051384
• Synonyms: Rabgef1^-
• Gene: Rabgef1 Location: Chr5:130200644-130243178 bp, + strand Genetic Position: Chr5, 68.78 cM, cytoband F
• Alliance: Rabgef1^tm1Glli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91790
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette in inverse orientation replaced the 3' portion of exon3. Protein product was undetectable in bone marrow derived cultured mast cells. (J:91790)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rabgef1 Mutation: 67 strains or lines available

References

• Original: J:91790 Tam SY, et al., RabGEF1 is a negative regulator of mast cell activation and skin inflammation. Nat Immunol. 2004 Aug;5(8):844-52
• All: 4 reference(s)