Rr29^Hxl3
Chemically induced Allele Detail

Summary

• Symbol: Rr29^Hxl3
• Name: regulatory region 29; hemimelic extra toes-like 3
• MGI ID: MGI:3051414
• Synonyms: M100081, Shh^Hxl3
• Gene: Rr29 Location: Chr5:29519879-29520665 bp
• Alliance: Rr29^Hxl3 page

Skeletal phenotypes of Rr29^Hx/Rr29^Hx and Rr29^Hxl3/Shh⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Modified regulatory region)
• Mutation: Single point mutation
• Rr29^Hxl3 involves 1 genes/genome features (Lmbr1) View all
• Mutation details: Generated by a large-scale ENU mutagenesis screen in RIKEN GSC. This mutation is the result of an A-to-G transition in a conserved Shh enhancer element located in intron 5 of the Lmbr1 gene. The mutation is located 145 bp 5' of the Hx mutation.
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr29 Mutation: 2 strains or lines available

References

• Original: J:87798 Sagai T, et al., Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh). Mamm Genome. 2004 Jan;15(1):23-34
• All: 3 reference(s)