Hprt1^{tm1(Ggt1-Agtr1)Cof}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Ggt1-Agtr1)Cof}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Thomas M Coffman
• MGI ID: MGI:3051543
• Synonyms: Gamma-GT-AT1A
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Ggt1-Agtr1)Cof} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91837
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm1(Ggt1-Agtr1)Cof} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Agtr1a (MGI:87964)

• Mutation details: A vector containing the P1 portion of the promoter from the rat Ggtp gene, mouse Agtr1a and the pA signal, as well as the human HPRT promoter, exon 1 and mouse Hprt exon 2 was inserted into ES cells with a deletion proximal to exon 3. Southern blot analysis confirmed recombination in ES cells. RT-PCR showed that the inserted sequence was expressed in transgenic kidneys. (J:91837)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:91837 Le TH, et al., A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics. 2004 Aug 11;18(3):290-8
• All: 1 reference(s)