Ina^tm1Jpj
Targeted Allele Detail

Summary

• Symbol: Ina^tm1Jpj
• Name: internexin neuronal intermediate filament protein, alpha; targeted mutation 1, Jean-Pierre Julien
• MGI ID: MGI:3051627
• Synonyms: alpha-internexin^-
• Gene: Ina Location: Chr19:47003137-47013766 bp, + strand Genetic Position: Chr19, 39.07 cM
• Alliance: Ina^tm1Jpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55800
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the first exon and first intron was replaced by a lacZ-neomycin fusion gene, such that beta-galactosidase should be expressed under the control of the endogenous promoter. Northern and western blot analysis demonstrated an absence of encoded mRNA and protein, respectively, in homozygous mice. (J:55800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ina Mutation: 14 strains or lines available

References

• Original: J:55800 Levavasseur F, et al., No requirement of alpha-internexin for nervous system development and for radial growth of axons. Brain Res Mol Brain Res. 1999 May 21;69(1):104-12
• All: 4 reference(s)