Cnp^tm1(cre)Kan
Targeted Allele Detail

Summary

• Symbol: Cnp^tm1(cre)Kan
• Name: 2',3'-cyclic nucleotide 3' phosphodiesterase; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:3051635
• Synonyms: Cnp1^Cre, Cnp^Cre, CNP^cre, CNP-Cre, CNP/Cre
• Gene: Cnp Location: Chr11:100465765-100472565 bp, + strand Genetic Position: Chr11, 63.47 cM
• Alliance: Cnp^tm1(cre)Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91814
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• Cnp^tm1(cre)Kan expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cnp (MGI:88437)

• Mutation details: The entire coding region was replaced with a Cre-PGKpuro cassette. RT-PCR indicated lack of endogenous transcript and presence of Cre in mutants. Western blot confirmed that no endogenous protein was present in mutant brain lysates. (J:91814)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cnp (mouse) Summary of all recombinase alleles driven by Cnp. Comparative matrix view of recombinase activities Alliance mouse Cnp gene page

Disease models

Expression

In Mice Carrying this Mutation:	6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnp Mutation: 27 strains or lines available

References

• Original: J:91814 Lappe-Siefke C, et al., Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet. 2003 Mar;33(3):366-74
• All: 182 reference(s)