Ptprn2^tm1Aln
Targeted Allele Detail

Summary

• Symbol: Ptprn2^tm1Aln
• Name: protein tyrosine phosphatase receptor type N polypeptide 2; targeted mutation 1, Abner Louis Notkins
• MGI ID: MGI:3051779
• Synonyms: IA-2Beta^-
• Gene: Ptprn2 Location: Chr12:116449340-117240469 bp, + strand Genetic Position: Chr12, 62.65 cM, cytoband F
• Alliance: Ptprn2^tm1Aln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91889
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced part of the 5' upstream promoter, exon 1 and part of intron 1, including the AUG start codon, 106 additional codons and a 5' UTR of at least 145 nucleotides. Northern blot indicated absence of transcript in brains of mutant mice. Further confirmation was provided by Western blot analysis showing lack of wild-type protein in brains of mutant mice. (J:91889)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprn2 Mutation: 69 strains or lines available

References

• Original: J:91889 Kubosaki A, et al., Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes. 2004 Jul;53(7):1684-91
• All: 11 reference(s)