Daxx^tm1Maul
Targeted Allele Detail

Summary

• Symbol: Daxx^tm1Maul
• Name: Fas death domain-associated protein; targeted mutation 1, Gerd G Maul
• MGI ID: MGI:3051780
• Synonyms: Daxx^-
• Gene: Daxx Location: Chr17:34128388-34134564 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Daxx^tm1Maul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91881
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced part of exon 3 and all of exons 4-7, eliminating the last 512 amino acids. The first 227 amino acids were putatively unstable as no transcript was detected in Northern or Western blot. PCR of cell lines confirmed recombination in mutants. (J:91881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Daxx Mutation: 34 strains or lines available

References

• Original: J:91881 Ishov AM, et al., Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. J Cell Sci. 2004 Sep 1;117(Pt 17):3807-20
• All: 1 reference(s)