Grap2^tm1Eac
Targeted Allele Detail

Summary

• Symbol: Grap2^tm1Eac
• Name: GRB2-related adaptor protein 2; targeted mutation 1, Edward A Clark
• MGI ID: MGI:3051853
• Synonyms: Gads^-
• Gene: Grap2 Location: Chr15:80456798-80537055 bp, + strand Genetic Position: Chr15, 37.88 cM, cytoband E2
• Alliance: Grap2^tm1Eac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3, encompassing the majority of the transcript including the ATG, were replaced with a neomycin resistance gene via homologous recombination. Southern blot confirmed recombination. Intracellular staining of thymocytes confirmed lack of protein in mutants. (J:92023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grap2 Mutation: 23 strains or lines available

References

• Original: J:92023 Yankee TM, et al., The Gads (GrpL) adaptor protein regulates T cell homeostasis. J Immunol. 2004 Aug 1;173(3):1711-20
• All: 5 reference(s)