Krt12^tm1Wwk
Targeted Allele Detail

Summary

• Symbol: Krt12^tm1Wwk
• Name: keratin 12; targeted mutation 1, Winston W Y Kao
• MGI ID: MGI:3051854
• Gene: Krt12 Location: Chr11:99306492-99313085 bp, - strand Genetic Position: Chr11, 62.92 cM
• Alliance: Krt12^tm1Wwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38023
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-7 and intron 7 were replaced with a neomycin resistance gene. Immunohistochemistry, Western blot, Northern blot and in situ hybridization confirmed lack of gene expression. (J:38023)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt12 Mutation: 24 strains or lines available

References

• Original: J:38023 Kao WW, et al., Keratin 12-deficient mice have fragile corneal epithelia. Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2572-84
• All: 2 reference(s)