Gja1^tm1Gfi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm1Gfi
• Name: gap junction protein, alpha 1; targeted mutation 1, Glenn I Fishman
• MGI ID: MGI:3051881
• Synonyms: Cx43^fl, Cx43^flox
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm1Gfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91971
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted into the single intron and a third loxP site was inserted in exon2 just downstream of the open reading frame. The targeting event did not affect gene expression. (J:91971)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:91971 Gutstein DE, et al., Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res. 2001 Feb 16;88(3):333-9
• All: 12 reference(s)