Ciapin1^tm1Yzka
Targeted Allele Detail

Summary

• Symbol: Ciapin1^tm1Yzka
• Name: cytokine induced apoptosis inhibitor 1; targeted mutation 1, Yuzuru Kanakura
• MGI ID: MGI:3051894
• Gene: Ciapin1 Location: Chr8:95546432-95564986 bp, - strand Genetic Position: Chr8, 46.86 cM
• Alliance: Ciapin1^tm1Yzka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90889
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin resistance gene in the targeting construct. Southern blot and PCR confirmed recombination in mutant mice and Western blot indicated gene expression was reduced in heterozygotes and completely lost in homozygous mutants. (J:90889)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ciapin1 Mutation: 29 strains or lines available

References

• Original: J:90889 Shibayama H, et al., Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis. J Exp Med. 2004 Feb 16;199(4):581-92
• All: 3 reference(s)