Hhat^tm2Ptch
Targeted Allele Detail

Summary

• Symbol: Hhat^tm2Ptch
• Name: hedgehog acyltransferase; targeted mutation 2, Pao-Tien Chuang
• MGI ID: MGI:3051901
• Synonyms: SkndeltaE9
• Gene: Hhat Location: Chr1:192195133-192453546 bp, - strand Genetic Position: Chr1, 97.55 cM
• Alliance: Hhat^tm2Ptch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89228
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A loxP site was inserted upstream of exon 9 and a FRT-flanked PGK-neo downstream, with a loxP site at the most 3'end. Crossing with Cre-deleter mice excised the floxed sequence, removing exon 9 and the neo. Exon 9 contains predicted active sites for an acyltransferase. (J:89228)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hhat Mutation: 27 strains or lines available

References

• Original: J:89228 Chen MH, et al., Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
• All: 1 reference(s)