Shh^tm1Ptch
Targeted Allele Detail

Summary

• Symbol: Shh^tm1Ptch
• Name: sonic hedgehog; targeted mutation 1, Pao-Tien Chuang
• MGI ID: MGI:3051902
• Synonyms: Shh^C25S
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^tm1Ptch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89228
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Single point mutation
• Mutation details: A single base pair change (G-to-C) resulted in a cysteine to serine change at amino acid position 25 (p.C25S). An FRT site flanked neomycin resistance gene cassette was inserted downstream of exon 1. (J:89228)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

References

• Original: J:89228 Chen MH, et al., Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
• All: 1 reference(s)