Slc17a7^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Slc17a7^tm1Bros
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; targeted mutation 1, Nils Brose
• MGI ID: MGI:3051945
• Synonyms: Slc17a7^tm1Rmnd, VGLUT1^-
• Gene: Slc17a7 Location: Chr7:44813373-44825566 bp, + strand Genetic Position: Chr7, 29.16 cM
• Alliance: Slc17a7^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region between the ATG and the fifth coding exon was replaced with a synaptobrevin 2-enhanced yellow fluorescent protein minigene and a floxed neo. Southern blot and PCR confirmed successful targeting. Expression of the EYFP was not detected. (J:89958)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc17a7 Mutation: 40 strains or lines available

References

• Original: J:89958 Wojcik SM, et al., An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7158-63
• All: 14 reference(s)