Rph3al^tm1Sse
Targeted Allele Detail

Summary

• Symbol: Rph3al^tm1Sse
• Name: rabphilin 3A-like (without C2 domains); targeted mutation 1, Susumu Seino
• MGI ID: MGI:3051976
• Synonyms: Noc2^-
• Gene: Rph3al Location: Chr11:75721825-75829255 bp, - strand Genetic Position: Chr11, 45.92 cM, cytoband B4
• Alliance: Rph3al^tm1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90669
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo in reverse orientation to transcription. Northern blot confirmed lack of transcript and Western blot showed no protein in mutant tissues. (J:90669)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rph3al Mutation: 20 strains or lines available

References

• Original: J:90669 Matsumoto M, et al., Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8313-8
• All: 2 reference(s)