Slc29a1^tm1Msg
Targeted Allele Detail

Summary

• Symbol: Slc29a1^tm1Msg
• Name: solute carrier family 29 (nucleoside transporters), member 1; targeted mutation 1, Robert O Messing
• MGI ID: MGI:3052066
• Synonyms: ENT1-
• Gene: Slc29a1 Location: Chr17:45896126-45910532 bp, - strand Genetic Position: Chr17, 22.59 cM, cytoband C
• Alliance: Slc29a1^tm1Msg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92100
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct included exons 2-4 of the gene and a neomycin cassette flanked by loxP sequences. Clones were transfected with a Cre plasmid. ES cell lines showing a deletion of exons 2-4 and the neomycin cassette were selected for microinjection. The mutation was confirmed by PCR, Southern blot and in situ hybridization. (J:92100)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc29a1 Mutation: 42 strains or lines available

Notes

ES cell line derived from 129X1/SvJ

References

• Original: J:92100 Choi DS, et al., The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference. Nat Neurosci. 2004 Aug;7(8):855-61
• All: 25 reference(s)