Ntrk1^{tm2(Ntrk3)Apat}
Targeted Allele Detail

Summary

• Symbol: Ntrk1^{tm2(Ntrk3)Apat}
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 2, Ardem Patapoutian
• MGI ID: MGI:3052071
• Synonyms: TrkA^TrkC
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^{tm2(Ntrk3)Apat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92099
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting construct containing IRES, rat Ntrk3 cDNA, SV40 polyA, and a floxed PGK-neo was inserted after the first 40 bp of exon 2, deleting exons 3-6. Crossing with Actb-cre mice excised the floxed neo. Southern blot confirmed recombination. RT-PCR of dorsal root ganglia of heterozygotes shows expression of both Ntrk1 and the inserted Ntrk3. (J:92099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 62 strains or lines available

References

• Original: J:92099 Moqrich A, et al., Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci. 2004 Aug;7(8):812-8
• All: 2 reference(s)