Sox2^tm3Skn
Targeted Allele Detail

Summary

• Symbol: Sox2^tm3Skn
• Name: SRY (sex determining region Y)-box 2; targeted mutation 3, Silvia K Nicolis
• MGI ID: MGI:3052123
• Synonyms: Sox2^{deltaENHdeltaneo}
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm3Skn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92063
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo replaced an upstream neural cell-specific enhancer. Crossing with CMV-Cre mice excised the floxed neo, leaving a single loxP site. (J:92063)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:92063 Ferri AL, et al., Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development. 2004 Aug;131(15):3805-19
• All: 3 reference(s)