Tg(Myog-Ntf3)5160Wds
Transgene Detail

Summary

• Symbol: Tg(Myog-Ntf3)5160Wds
• Name: transgene insertion 5160, William D Snider
• MGI ID: MGI:3052131
• Synonyms: myo-NT-3
• Transgene: Tg(Myog-Ntf3)5160Wds Location: unknown
• Alliance: Tg(Myog-Ntf3)5160Wds page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myog-Ntf3)5160Wds expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ntf3 (MGI:97380)

• Mutation details: This transgene consists of a 1.58kb fragment of the myogenin promoter, an 800 bp cDNA of the murine Ntf3 gene, and 2.1 kb of the human HGH gene including exons, introns, and a polyadenylation signal. Increased Ntf3 expression is seen the muscles from E11.5 to 5 weeks after birth. Three lines were generated (5150, 5158, 5160), only 5160 was selected for further study. (J:43444)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:43444 Wright DE, et al., Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3. Neuron. 1997 Sep;19(3):503-17
• All: 4 reference(s)