Disp1^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Disp1^tm1Amc
• Name: dispatched RND transporter family member 1; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:3052133
• Synonyms: Disp1^delta2
• Gene: Disp1 Location: Chr1:182867830-183003086 bp, - strand Genetic Position: Chr1, Syntenic
• Alliance: Disp1^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92058
• Parent Cell Line: AV3 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to flank exon 2, containing an initiation site and N-terminal 168 amino acids, with loxP sites. Cre expression in the germ line excised exon 2, leaving a single loxP site. Analysis of transcripts suggests that, in the absence of exon 2, exon 1B was replaced by exon 1A, which was spliced to exon 3, thereby allowing translation from an initiation codon in exon 4. The result was a N-terminal truncated transcript. Southern blot confirmed absence of exon 2 in mutant mice with this putatively hypomorphic allele. (J:92058)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disp1 Mutation: 61 strains or lines available

References

• Original: J:92058 Tian H, et al., Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. (RETRACTION Development (2005) 132 (24): 5615). Development. 2004 Aug;131(16):4021-33
• All: 2 reference(s)