Hr^tm1Cct
Targeted Allele Detail

Summary

• Symbol: Hr^tm1Cct
• Name: lysine demethylase and nuclear receptor corepressor; targeted mutation 1, Catherine C Thompson
• MGI ID: MGI:3052135
• Synonyms: Hr^-
• Gene: Hr Location: Chr14:70789652-70810988 bp, + strand Genetic Position: Chr14, 36.32 cM
• Alliance: Hr^tm1Cct page

Characterization of the Hr^tm1Cct/Hr^tm1Cct mouse

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92053
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8-10 were replaced with a floxed PGK-neo cassette. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. (J:92053)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hr Mutation: 87 strains or lines available

References

• Original: J:92053 Zarach JM, et al., The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development. 2004 Sep;131(17):4189-200
• All: 3 reference(s)