Tg(TcrLCMV)1Aox
Transgene Detail

Summary

• Symbol: Tg(TcrLCMV)1Aox
• Name: transgene insertion 1, Annette Oxenius
• MGI ID: MGI:3052138
• Synonyms: Smarta1, SMARTA1 TCR-transgenic
• Transgene: Tg(TcrLCMV)1Aox Location: unknown
• Alliance: Tg(TcrLCMV)1Aox page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcrLCMV)1Aox expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Two expression cassettes, one containing a 17.5 kb Tcr Valpha2.3-JalphaDK1 rearrangement and the other containing a 19.5 kb Tcr Vbeta8.3-Jbeta2.5 rearrangement, were coinjected into fertilized eggs. The injected fragments are specific for the LCMV GP-derived epitope P13 (amino acids 61-80) in the context of H2-IA^b. Two transgenic mouse lines (referred to as Smarta1 and Smarta2) were derived from a single transgenic founder. Each sub-line was given its own allele because of phenotypic differences between the sub-lines. The CD4:CD8 ratio of single positive thymocytes for this line is 27:1. (J:92228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92228 Oxenius A, et al., Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol. 1998 Jan;28(1):390-400
• All: 49 reference(s)