Zic5^tm1Jaru
Targeted Allele Detail

Summary

• Symbol: Zic5^tm1Jaru
• Name: zinc finger protein of the cerebellum 5; targeted mutation 1, Jun Aruga
• MGI ID: MGI:3052154
• Synonyms: Deltaneo
• Gene: Zic5 Location: Chr14:122696572-122703127 bp, - strand Genetic Position: Chr14, 65.96 cM, cytoband E5
• Alliance: Zic5^tm1Jaru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92220
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to delete 2.3 kb of exon one containing the ATG and encoding three of the five zinc finger motifs. A floxed neo replaced the sequence and was subsequently excised by crossing with mice expressing Cre in the germ line. Immunohistochemistry of mutant hindbrain samples showed no significant immunoreactivity. (J:92220)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zic5 Mutation: 37 strains or lines available

References

• Original: J:92220 Inoue T, et al., Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol. 2004 Jun 1;270(1):146-62
• All: 1 reference(s)