Pias1^tm1Kes
Targeted Allele Detail

Summary

• Symbol: Pias1^tm1Kes
• Name: protein inhibitor of activated STAT 1; targeted mutation 1, Ke Shuai
• MGI ID: MGI:3052227
• Synonyms: Pias1^-
• Gene: Pias1 Location: Chr9:62785648-62888161 bp, - strand Genetic Position: Chr9, 33.91 cM
• Alliance: Pias1^tm1Kes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-12 were replaced with a PGK-neo cassette. Transcript was absent in Northern blot of mutant testis and Western blot indicated no protein was present in mutant BMM, spleen or thymus. (J:92167)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pias1 Mutation: 43 strains or lines available

References

• Original: J:92167 Liu B, et al., PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004 Sep;5(9):891-8
• All: 5 reference(s)