Dusp10^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Dusp10^tm1Flv
• Name: dual specificity phosphatase 10; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3052343
• Synonyms: Dusp10^tm1Cdo, Mkp5-
• Gene: Dusp10 Location: Chr1:183766575-183807833 bp, + strand Genetic Position: Chr1, 88.2 cM, cytoband H5
• Alliance: Dusp10^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92104
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 and the 5' flanking sequences. Messenger RNA analysis of gene expression in T cells confirmed the null mutation. (J:92104)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Dusp10^tm1Flv/Dusp10^tm1Flv	involves: 129S6/SvEvTac

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	√
decreased T cell proliferation	√
hematopoietic system	√
decreased T cell proliferation	√
increased activated T cell number	√
immune system	√
increased activated T cell number	√
abnormal adaptive immunity	√
decreased T cell proliferation	√
increased susceptibility to type I hypersensitivity reaction	√
abnormal cytokine secretion	√
increased interferon-gamma secretion	√
abnormal interleukin secretion	√
increased tumor necrosis factor secretion	√
decreased susceptibility to experimental autoimmune encephalomyelitis	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp10 Mutation: 29 strains or lines available

References

• Original: J:92104 Zhang Y, et al., Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 2004 Aug 12;430(7001):793-7
• All: 14 reference(s)