Gt(ROSA)26Sor^tm1(Luc)Kael
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Luc)Kael
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, William G Kaelin
• MGI ID: MGI:3052356
• Synonyms: Gt(ROSA)26Sor^{tm1(Luc)Kaelin}, ROSA26-Fluc, ROSA26 L-S-L-Luc
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Luc)Kael page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92043
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus is interrupted by a construct comprising a loxP site, a neomycin resistance cassette with a strong, triple SV40 polyadenylation signal, and a second loxP site in the same orientation as the first followed by the cDNA sequence encoding firefly luciferase and the bovine growth hormone polyadenylation signal. In cells in which cre recombinase is expressed, the DNA between the loxP sites is excised, along with one loxP site, permitting expression of the luciferase gene under control of the ubiquitous ROSA26 promoter. (J:92043)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^tm1(Luc)Kael

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 994 strains or lines available

References

• Original: J:92043 Safran M, et al., Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Mol Imaging. 2003 Oct;2(4):297-302
• All: 69 reference(s)