Gja8^dcm
Spontaneous Allele Detail

Summary

• Symbol: Gja8^dcm
• Name: gap junction protein, alpha 8; dense cataract and microphthalmia
• MGI ID: MGI:3052418
• Gene: Gja8 Location: Chr3:96820882-96833336 bp, - strand
• Alliance: Gja8^dcm page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: Mapping and sequence analysis of the dense cataract and microphthalmia (dcm) mouse identified a single nucleotide change of G to C at position 64 that results in the amino acid glycine to arginine substitution at position 22 (p.G22R). (J:292883)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja8 Mutation: 33 strains or lines available

References

• Original: J:91434 Kohale K, et al., Dense cataract and microphthalmia--new spontaneous mutation in BALB/c mice. Comp Med. 2004 Jun;54(3):275-9
• All: 2 reference(s)