Tmbim6^Gt1Jcre
Gene trapped Allele Detail

Summary

• Symbol: Tmbim6^Gt1Jcre
• Name: transmembrane BAX inhibitor motif containing 6; gene trap 1, John C Reed
• MGI ID: MGI:3052422
• Synonyms: BI-1^-
• Gene: Tmbim6 Location: Chr15:99290828-99307930 bp, + strand Genetic Position: Chr15, 56.13 cM, cytoband F3
• Alliance: Tmbim6^Gt1Jcre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91831
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: This allele contains a single proviral insertion in reverse orientation between exons 7 and 8. Northern blot demonstrated presence of a truncated transcript present at very low levels in most tissues, except for thymus and lung, where the truncated transcripts were more significant. (J:91831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmbim6 Mutation: 20 strains or lines available

References

• Original: J:91831 Chae HJ, et al., BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell. 2004 Aug 13;15(3):355-66
• All: 10 reference(s)