Tg(APOA1)1Rub
Transgene Detail

Summary

• Symbol: Tg(APOA1)1Rub
• Name: transgene insertion 1, Edward M Rubin
• MGI ID: MGI:3052540
• Synonyms: A1Tg, ApoA1^Tg, apoA-I/A-IKO, ApoA-I^tg, hA-I, hapoA1, hApoA-I/Tg, Hu apo AI
• Transgene: Tg(APOA1)1Rub Location: unknown
• Alliance: Tg(APOA1)1Rub page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOA1)1Rub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOA1 (335)

  Apoa1

  (MGI:88049)

• The transgene contains the human apolipoprotein A-I gene including the promoter. (J:42425)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice display a two fold increase in total plasma cholesterol levels and greater than a four fold decrease in the levels of mouse APOA1. Two lines were produced, A2 and A16.

References

• Original: J:42425 Rubin EM, et al., Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):434-8
• All: 50 reference(s)