Tg(H2-Ea^d)12Lt
Transgene Detail

Summary

• Symbol: Tg(H2-Ea^d)12Lt
• Name: transgene insertion 12, Edward H Leiter
• MGI ID: MGI:3052550
• Synonyms: Tg(I-Ealpha^d,line 12)3Lt
• Transgene: Tg(H2-Ea^d)12Lt Location: unknown
• Alliance: Tg(H2-Ea^d)12Lt page

Transgene origin

• Strain of Origin: NOD/ShiLt

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-Ea^d)12Lt expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-I (MGI:95903)

• Mutation details: The construct contains a complete H2-Ea^d gene from the BALB/cByJ mouse including flanking sequence. One copy of the transgene integrated into the genome of line 12 whereas four copies are present in line 5. (J:36435)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Diabetes incidence in transgenic mice carrying line 12 is greatly reduced (25% of females, 0% of males) where H2-Ea expression on antigen presenting cells is comparable to BALB/cByJ controls. Although the presence of the transgene in both lines 5 and 12 confers protective influence from IDDM pathologies that affect pancreatic beta cells, autoimmune pathologies effecting other tissues (submandibular salivary, thyroid, kidney) are observed. Histologic examination of the pancreas reveals perivascular/periductal infiltration and peri-insulitus.

References

• Original: J:36435 Hanson MS, et al., Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol. 1996 Aug 1;157(3):1279-87
• All: 1 reference(s)