Tg(CD3E)26Cpt
Transgene Detail

Summary

• Symbol: Tg(CD3E)26Cpt
• Name: transgene insertion 26, Cox Terhorst
• MGI ID: MGI:3052629
• Synonyms: CD3epsilon, CD3epsilontg26, tgE26, Tgepsilon26
• Transgene: Tg(CD3E)26Cpt Location: Chr17:25708849-26016019 bp Genetic Position: Chr17, Syntenic
• Alliance: Tg(CD3E)26Cpt page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD3E)26Cpt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD3E (916)

  Cd3e	(MGI:88332)

• Mutation details: The transgene contains a human gene encoding the CD3 antigen, epsilon polypeptide sequences. 30-35 copies of the transgene integrated into the genome between Sstr5 and Metrn on Chromosome 17, accompanied by duplication of the neighboring genomic region spanning 323 kb. Genes surrounding the integrated tg26 transgene are not disrupted. (J:81711, J:168333)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:81711 Wang B, et al., A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9402-6
• All: 31 reference(s)