Tg(Neurog3-cre)C1Able
Transgene Detail

Summary

• Symbol: Tg(Neurog3-cre)C1Able
• Name: transgene insertion C1, Andrew B Leiter
• MGI ID: MGI:3052639
• Synonyms: Neurgo3^TgBAC-Cre, Neurog3(cre), Neurog3Cre, ngn3-Cre, Tg(Neurog3-cre)#Able
• Transgene: Tg(Neurog3-cre)C1Able Location: unknown
• Alliance: Tg(Neurog3-cre)C1Able page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Neurog3-cre)C1Able expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurog3 (MGI:893591)

• Mutation details: The Cre recombinase coding sequence, flanked by a nuclear localization signal and an SV40 polyadenylation site, was inserted just after the translation start site of the neurogenin 3 gene present in mouse BAC RP23-121F10, which also includes approximately 81 kb of 5' and 102 kb of 3' flanking DNA. Immunohistochemical analysis shows the same expression pattern for cre as for neurogenin 3 in adult and embryonic mice bearing this transgene. Cre recombinase activity is seen in cell types of pancreas, stomach, small intestine and colon that express or are descended from cells that express neurogenin 3 during development. (J:92204)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (mouse) Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities Alliance mouse Neurog3 gene page

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Tg(Neurog3-cre)C1Able/0 Tg(RNU6-EGFP,-RNAi:Dpp7)#Bhub/0	involves: 129 * C57BL/6 * CD-1
cn2	Gt(ROSA)26Sor^tm1(Notch1)Dam/Gt(ROSA)26Sor^+ Tg(Neurog3-cre)C1Able/0	involves: 129S4/SvJaeSor
cn3	Onecut1^tm1.1Mga/Onecut1^tm1.1Mga Tg(Neurog3-cre)C1Able/0	involves: 129S6/SvEvTac * C57BL/6 * SJL
cn4	Nkx6-1^tm1.1Msan/Nkx6-1^+ Pdx1^tm1Cvw/Pdx1^+ Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL
cn5	Nkx6-1^tm1Jlr/Nkx6-1^tm1.1Msan Tg(CAG-Bgeo/GFP)21Lbe/0 Tg(Neurog3-cre)C1Able/0	involves: 129/Sv * C57BL/6 * SJL
cn6	Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Neurog3-cre)C1Able/0	involves: BALB/c * C57BL/6
cn7	Syt13^tm1c(EUCOMM)Hmgu/Syt13^tm1c(EUCOMM)Hmgu Tg(Neurog3-cre)C1Able/0	involves: C57BL/6J * C57BL/6N

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7
show or hide all annotated terms
adipose tissue	√
increased epididymal fat pad weight	√
increased abdominal fat pad weight	√
increased percent body fat/body weight	√
behavior/neurological	√
abnormal eating behavior	√
cellular					√
abnormal pancreatic beta cell differentiation					√
digestive/alimentary system		√
abnormal pancreatic duct morphology		√
endocrine/exocrine glands	N	√	N	√	√	√	√
endocrine/exocrine gland phenotype	N	N	N		N	N
abnormal pancreatic duct morphology		√
abnormal pancreatic islet morphology				√
decreased pancreatic alpha cell number						√
increased pancreatic alpha cell number				√	√
decreased pancreatic beta cell number				√	√
increased pancreatic beta cell number						√
decreased pancreatic delta cell number						√
increased pancreatic delta cell number					√
decreased pancreatic epsilon cell number						√
increased pancreatic epsilon cell number					√
absent pancreatic islets		√
abnormal pancreas development		√
abnormal endocrine pancreas development							√
abnormal pancreatic beta cell differentiation					√
growth/size/body	√	√
decreased body weight		√
increased liver weight	√
homeostasis/metabolism	√	√	N		√	N
homeostasis/metabolism phenotype			N			N
increased circulating glucose level	√
hyperglycemia	√	√			√
increased circulating insulin level	√
dehydration					√
impaired glucose tolerance	√
insulin resistance	√
liver/biliary system	√
increased liver weight	√
hepatic steatosis	√
mortality/aging		√			√
postnatal lethality, complete penetrance		√			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

50 assay results 11 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

This is one of two independent lines demonstrating identical expression patterns.

References

• Original: J:92204 Schonhoff SE, et al., Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol. 2004 Jun 15;270(2):443-54
• All: 95 reference(s)