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Tg(Cyp1a1-cre)1Dwi
Transgene Detail
Summary
Symbol: Tg(Cyp1a1-cre)1Dwi
Name: transgene insertion 1, Douglas J Winton
MGI ID: MGI:3052655
Synonyms: Ah-cre, AhCre, CreCYP1A1
Transgene: Tg(Cyp1a1-cre)1Dwi  Location: unknown  
Alliance: Tg(Cyp1a1-cre)1Dwi page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    beta-naphthoflavone
Mutation:    Insertion
 
Tg(Cyp1a1-cre)1Dwi expression driven by 1 gene
 
Mutation detailsThe rat Cyp1a1 promoter drives the expression of cre recombinase. Halogenated aromatic hydrocarbon inducible cre expression is seen in multiple tissues. Four lines were generated but only one was characterized in detail. (J:90759, J:92092)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cyp1a1 (rat)
Summary of all recombinase alleles driven by Cyp1a1.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
involves: 129 * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: 129P2/OlaHsd * C57BL/6 * CBA
 
involves: C57BL/6 * CBA
 
involves: C57BL/6 * CBA
 
involves: C57BL/6 * CBA
 
involves: C57BL/6 * CBA * SJL
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
                     
behavior/neurological
abnormal behavior
cellular
abnormal intestinal goblet cell morphology
increased hepatocyte apoptosis
increased small intestinal crypt cell apoptosis
abnormal enterocyte proliferation
abnormal small intestinal crypt cell proliferation
increased DNA replication
abnormal translation
digestive/alimentary system
N N N
digestive/alimentary phenotype
N N N
abnormal intestinal goblet cell morphology
increased small intestinal crypt cell apoptosis
abnormal enterocyte proliferation
abnormal small intestinal crypt cell proliferation
abnormal intestinal epithelium morphology
abnormal crypts of Lieberkuhn morphology
abnormal small intestine morphology
abnormal small intestine crypts of Lieberkuhn morphology
decreased Paneth cell number
ectopic Paneth cells
abnormal small intestinal villus morphology
decreased small intestinal villus height
decreased small intestinal villus size
endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology
abnormal small intestine crypts of Lieberkuhn morphology
decreased Paneth cell number
ectopic Paneth cells
increased pancreatic ductal adenocarcinoma incidence
growth/size/body
increased liver weight
homeostasis/metabolism
increased DNA replication
abnormal translation
immune system
liver inflammation
liver/biliary system
N
liver/biliary system phenotype
N
increased hepatocyte apoptosis
increased liver weight
liver inflammation
small liver
hepatic necrosis
hepatic steatosis
increased hepatocellular carcinoma incidence
mortality/aging
premature death
neoplasm
increased pancreatic ductal adenocarcinoma incidence
increased hepatocellular carcinoma incidence
increased lymphoma incidence
reproductive system
endometrium hyperplasia
View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Tg(Cyp1a1-cre)1Dwi
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:92092 Ireland H, et al., Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology. 2004 May;126(5):1236-46
All:  97 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory