Tg(CETP)UCTP20Pnu
Transgene Detail

Summary

• Symbol: Tg(CETP)UCTP20Pnu
• Name: transgene insertion UCTP20, Pharmacia & Upjohn
• MGI ID: MGI:3052658
• Synonyms: Tg(CETP)1Pnu
• Transgene: Tg(CETP)UCTP20Pnu Location: unknown
• Alliance: Tg(CETP)UCTP20Pnu page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Transgenic mice overexpress the simian plasma cholesteryl ester transfer protein under control of the mouse metallothionein (MT1) promoter. Four lines were characterized with mice exhibiting a negative correlation between plasma CETP activity and total plasma cholesterol, plasma apolipoprotein A-I levels (APOA1), and plasma APOAI to APOB ratio. This line, UCTP-20, was the highest expressor of the transgene and was selected for further study. Significant transgene expression was detected by Northern blotting in the liver, brain and heart. (J:92448)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(CETP)UCTP20Pnu/0	C57BL/6-Tg(CETP)UCTP20Pnu

Phenotypes:

Affected Systems	tg1
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cardiovascular system	√
increased susceptibility to atherosclerosis	√
homeostasis/metabolism	√
abnormal circulating cholesterol level	√
decreased circulating HDL cholesterol level	√
increased circulating LDL cholesterol level	√
increased circulating VLDL cholesterol level	√
abnormal circulating protein level	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92448 Marotti KR, et al., The role of cholesteryl ester transfer protein in primate apolipoprotein A-I metabolism. Insights from studies with transgenic mice. Arterioscler Thromb. 1992 Jun;12(6):736-44
• All: 11 reference(s)