Adam1a^tm1Tba
Targeted Allele Detail

Summary

• Symbol: Adam1a^tm1Tba
• Name: a disintegrin and metallopeptidase domain 1a; targeted mutation 1, Tadashi Baba
• MGI ID: MGI:3052660
• Synonyms: Adam1a^-
• Gene: Adam1a Location: Chr5:121656667-121659758 bp, - strand Genetic Position: Chr5, 61.84 cM
• Alliance: Adam1a^tm1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92271
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The protein-coding region containing the pro-, metalloprotease, disintegrin and cysteine rich domains were replaced with a neo via homologous recombination. Northern blot of mutant testes indicated lack of transcript and Western blot of testicular germ cells of mutants showed complete absence of the precursor form of the protein. (J:92271)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adam1a Mutation: 24 strains or lines available

References

• Original: J:92271 Nishimura H, et al., Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface. J Biol Chem. 2004 Aug 13;279(33):34957-62
• All: 2 reference(s)