Tg(Ins2-TAg)1Lt
Transgene Detail

Summary

• Symbol: Tg(Ins2-TAg)1Lt
• Name: transgene insertion 1, Edward H Leiter
• MGI ID: MGI:3052662
• Synonyms: Tg(RipTAg)1Lt
• Transgene: Tg(Ins2-TAg)1Lt Location: unknown
• Alliance: Tg(Ins2-TAg)1Lt page

Transgene origin

• Strain of Origin: NOD/ShiLt

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains rat insulin 2 promoter (Rip) and the wild-type allele of the SV40 large T antigen (TAg) gene. (J:92449)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ins2-TAg)1Lt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice on an NOD/Lt genetic background develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic.

References

• Original: J:92449 Hamaguchi K, et al., NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 1991 Jul;40(7):842-9
• All: 8 reference(s)