Mknk1^tm1Fuku
Targeted Allele Detail

Summary

• Symbol: Mknk1^tm1Fuku
• Name: MAP kinase-interacting serine/threonine kinase 1; targeted mutation 1, Rikiro Fukunaga
• MGI ID: MGI:3052673
• Synonyms: Mnk1^-
• Gene: Mknk1 Location: Chr4:115696395-115736447 bp, + strand Genetic Position: Chr4, 53.06 cM
• Alliance: Mknk1^tm1Fuku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92274
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6 were replaced with a neomycin resistance gene. Southern blot confirmed recombination and Western blot of mutant spleen demonstrated a lack of protein. (J:92274)

Tumor Data

List all tumor models in MMHCdb carrying Mknk1^tm1Fuku

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mknk1 Mutation: 26 strains or lines available

References

• Original: J:92274 Ueda T, et al., Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol. 2004 Aug;24(15):6539-49
• All: 19 reference(s)