Tg(APOA2)3Rub
Transgene Detail

Summary

• Symbol: Tg(APOA2)3Rub
• Name: transgene insertion 3, Edward M Rubin
• MGI ID: MGI:3052677
• Synonyms: AII/Fu-9, apoA-II/A-IKO, hA-II, Hu apo AII
• Transgene: Tg(APOA2)3Rub Location: unknown
• Alliance: Tg(APOA2)3Rub page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOA2)3Rub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOA2 (336)

  Apoa2

  (MGI:88050)

• Mutation details: 5 kb of promoter sequence to the human APOA-I gene were fused to human APOA-II coding sequence. 10 copies of the transgene intergrated into the genome of this founder strain. In these mice, human APOA2 mRNA is found only in the liver. Transgenic mice express a dimeric form of human apolipoprotein A-II. Levels of murine HDL, APOA1, and APOA2 in transgenic mice were comparable to those found in normal wildtype siblings. (J:92450)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92450 Schultz JR, et al., Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. J Biol Chem. 1992 Oct 25;267(30):21630-6
• All: 6 reference(s)