Rad9a^tm1Lieb
Targeted Allele Detail

Summary

• Symbol: Rad9a^tm1Lieb
• Name: RAD9 checkpoint clamp component A; targeted mutation 1, Howard B Lieberman
• MGI ID: MGI:3052710
• Synonyms: Mrad9^-
• Gene: Rad9a Location: Chr19:4245195-4251661 bp, - strand Genetic Position: Chr19, 3.89 cM, cytoband A
• Alliance: Rad9a^tm1Lieb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Floxed exons 1 and 2 were excised following upon mating with mice ubiquitously expressing Cre recombinase. PCR confirmed recombination in ES cells and mice and Western blot indicated no protein was produced in mutant ES cells. (J:92282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rad9a Mutation: 27 strains or lines available

References

• Original: J:92282 Hopkins KM, et al., Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality. Mol Cell Biol. 2004 Aug;24(16):7235-48
• All: 2 reference(s)