Aadat^tm1Tag
Targeted Allele Detail

Summary

• Symbol: Aadat^tm1Tag
• Name: aminoadipate aminotransferase; targeted mutation 1, Danilo A Tagle
• MGI ID: MGI:3052711
• Synonyms: mKat-2^-
• Gene: Aadat Location: Chr8:60958966-60998711 bp, + strand Genetic Position: Chr8, 30.85 cM
• Alliance: Aadat^tm1Tag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92240
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a PGK-neo in reverse orientation, resulting in a frameshift downstream of the targeted region. Southern blot and PCR confirmed recombination. Northern blot showed no transcript in mutants and Western blot showed no protein was translated in mutant kidneys. (J:92240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aadat Mutation: 37 strains or lines available

References

• Original: J:92240 Yu P, et al., Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice. Mol Cell Biol. 2004 Aug;24(16):6919-30
• All: 6 reference(s)