Tinf2^tm1Yjc
Targeted Allele Detail

Summary

• Symbol: Tinf2^tm1Yjc
• Name: Terf1 (TRF1)-interacting nuclear factor 2; targeted mutation 1, Y Jeffrey Chiang
• MGI ID: MGI:3052712
• Synonyms: Tin2^-
• Gene: Tinf2 Location: Chr14:55912146-55919277 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Tinf2^tm1Yjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92239
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted into exon 1 upstream of the ATG. Southern blot and PCR confirmed recombination in mice. (J:92239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tinf2 Mutation: 14 strains or lines available

References

• Original: J:92239 Chiang YJ, et al., Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol. 2004 Aug;24(15):6631-4
• All: 2 reference(s)