Chst2^tm1Tmu
Targeted Allele Detail

Summary

• Symbol: Chst2^tm1Tmu
• Name: carbohydrate sulfotransferase 2; targeted mutation 1, Takashi Muramatsu
• MGI ID: MGI:3052713
• Synonyms: GlcNAc6ST-1, Gn6st^-, GST2^-
• Gene: Chst2 Location: Chr9:95282979-95289323 bp, - strand Genetic Position: Chr9, 50.11 cM, cytoband E3.2-3.3
• Alliance: Chst2^tm1Tmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92231
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' PAPS binding region in the catalytic domain was replaced with a neomycin resistance gene. Southern blot confirmed recombination and RT-PCR indicated no transcript was detected in mutant organs. (J:92231)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chst2 Mutation: 21 strains or lines available

References

• Original: J:92231 Uchimura K, et al., N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. J Biol Chem. 2004 Aug 13;279(33):35001-8
• All: 17 reference(s)