Klre1^tm1Tgi
Targeted Allele Detail

Summary

• Symbol: Klre1^tm1Tgi
• Name: killer cell lectin-like receptor family E member 1; targeted mutation 1, Masaru Taniguchi
• MGI ID: MGI:3052750
• Synonyms: KLRE-1^-
• Gene: Klre1 Location: Chr6:129554868-129562790 bp, + strand Genetic Position: Chr6, 63.41 cM
• Alliance: Klre1^tm1Tgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92262
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An EGFP-neo was inserted in frame 9 bp downstream of ATG. Southern blot and RT-PCR indicated recombination was successful and no wild-type transcript was present in mutant splenocytes. Flow cytometry showed lack of surface expression of the endogenous protein. GFP expression inversely correlated with the loss of Klre1 expression. (J:92262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klre1 Mutation: 20 strains or lines available

References

• Original: J:92262 Shimizu E, et al., Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1-deficient mice. Blood. 2004 Aug 1;104(3):781-3
• All: 1 reference(s)