Trex1^tm1Tld
Targeted Allele Detail

Summary

• Symbol: Trex1^tm1Tld
• Name: three prime repair exonuclease 1; targeted mutation 1, Tomas Lindahl
• MGI ID: MGI:3052754
• Synonyms: Trex1^-
• Gene: Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
• Alliance: Trex1^tm1Tld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92264
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette replaced sequence encoding amino acids 103-207 of the encoded peptide, including conserved exonuclease magnesium binding motifs II and III. RT-PCR showed no transcript present in mutant spleens. Mutant livers did not demonstrate protein in Western blot analysis. (J:92264)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trex1^tm1Tld

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Trex1 Mutation: 26 strains or lines available

References

• Original: J:92264 Morita M, et al., Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol. 2004 Aug;24(15):6719-27
• All: 31 reference(s)