Tg(Mt1)174Bri
Transgene Detail

Summary

• Symbol: Tg(Mt1)174Bri
• Name: transgene insertion 174, Ralph L Brinster
• MGI ID: MGI:3052794
• Synonyms: MT-TG, MTtrans, TgMTI
• Transgene: Tg(Mt1)174Bri Location: unknown
• Alliance: Tg(Mt1)174Bri page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1)174Bri expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mt1 (MGI:97171)

• Mutation details: The transgene contains mouse metallothionein 1 sequence with 10kb of upstream sequence and 7kb of downstream sequence. 56 copies of the transgene integrated in this line. (J:92452)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Atp7a^Mo-brJ/Atp7a^+ Mt1^tm1Bri/Mt1^tm1Bri Mt2^tm1Bri/Mt2^tm1Bri Tg(Mt1)174Bri/0	involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL
tg2	Tg(Mt1)174Bri/Tg(Mt1)174Bri	involves: C57BL/6 * SJL
tg3	Tg(Mt1)174Bri/0	B6.Cg-Tg(Mt1)174Bri/J
tg4	Tg(Mt1)174Bri/0	involves: C57BL/6 * SJL

Phenotypes:

Affected Systems	cx1	tg2	tg3	tg4
show or hide all annotated terms Sex:
cardiovascular system		√
abnormal response to cardiac infarction		√
decreased myocardial infarct size		√
digestive/alimentary system		√
abnormal intestinal mineral absorption		√
homeostasis/metabolism		√	√	√
abnormal response to cardiac infarction		√
decreased myocardial infarct size		√
abnormal mineral level				√
decreased susceptibility to xenobiotic induced morbidity/mortality			√
mortality/aging			√
decreased susceptibility to xenobiotic induced morbidity/mortality			√
normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:92452 Palmiter RD, et al., Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol Cell Biol. 1993 Sep;13(9):5266-75
• All: 25 reference(s)