Tg(Apoa2)1Lus
Transgene Detail

Summary

• Symbol: Tg(Apoa2)1Lus
• Name: transgene insertion 1, Aldons J Lusis
• MGI ID: MGI:3052796
• Transgene: Tg(Apoa2)1Lus Location: unknown
• Alliance: Tg(Apoa2)1Lus page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Apoa2)1Lus expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Apoa2 (MGI:88050)

• Mutation details: The transgene contains mouse apolipoprotein A-II sequence from Swiss 3T3 cells with 4.5 kb of upstream sequence and 8.5 kb of downstream sequence. About 10 copies of the transgene integrated into the genome. The apoA-II expressed from the Swiss 3T3 cell genomic clone carries a more basic apoA-II allele (found among many inbred strains of mice) than the C57BL/6J apoA-II allele. Expression of the transgene in the liver was 4-fold higher than endogenous gene expression. (J:92454)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92454 Hedrick CC, et al., Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice. J Biol Chem. 1993 Sep 25;268(27):20676-82
• All: 8 reference(s)