Ubp1^tm1Jmc
Targeted Allele Detail

Summary

• Symbol: Ubp1^tm1Jmc
• Name: upstream binding protein 1; targeted mutation 1, John M Cunningham
• MGI ID: MGI:3052819
• Synonyms: LBP-1a^-
• Gene: Ubp1 Location: Chr9:113760002-113806270 bp, + strand Genetic Position: Chr9, 64.14 cM, cytoband F2
• Alliance: Ubp1^tm1Jmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92266
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter, exon 1 and part of intron 1 were replaced with a neomycin resistance casette inserted in reverse orientation. Absence of transcription was confirmed by Northern blot analysis and RT-PCR (J:92266)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubp1 Mutation: 33 strains or lines available

References

• Original: J:92266 Parekh V, et al., Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors. Mol Cell Biol. 2004 Aug;24(16):7113-29
• All: 1 reference(s)