Tg(BCL2)22Wehi
Transgene Detail

Summary

• Symbol: Tg(BCL2)22Wehi
• Name: transgene insertion 22, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:3052827
• Synonyms: 22Wehi, C-Emu-bcl-2-22, Emu2-22, Emu-bcl-2, Emu-bcl-2-22, EmuBcl-2.22, SV40-E-hbcl-2-22
• Transgene: Tg(BCL2)22Wehi Location: unknown
• Alliance: Tg(BCL2)22Wehi page

Transgene origin

• Strain of Origin: (C57BL/6JWehi x SJL/JWehi)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(BCL2)22Wehi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: The transgene construct consists of the human BCL2 cDNA in association with the Emu immunoglobulin heavy chain enhancer and SV40 promoter. (J:93111)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Gt(ROSA)26Sor^tm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor^+ Cd79a^tm3(cre/ERT2)Reth/Cd79a^+ Tg(BCL2)22Wehi/0	involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi
cn2	Cd79a^tm1(cre)Reth/Cd79a^+ Dicer1^tm1Mmk/Dicer1^tm1Mmk Tg(BCL2)22Wehi/0	involves: BALB/c * C57BL/6JWehi * SJL/JWehi
cx3	Cd72^tm1Jrp/Cd72^tm1Jrp Tg(BCL2)22Wehi/0	either: (involves: 129P2/OlaHsd * C57BL/6JWehi * SJL/JWehi) or (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JWehi * SJL/JWehi)
cx4	Igkrs^tm1Nemz/Igkrs^tm1Nemz Tg(BCL2)22Wehi/?	involves: 129 * C57BL
cx5	Fnip1^Gt(RRM154)Byg/Fnip1^Gt(RRM154)Byg Tg(BCL2)22Wehi/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
cx6	Cd79b^tm1Mnz/Cd79b^tm1Mnz Tg(BCL2)22Wehi/0 Tg(IghelMD4)4Ccg/0 Tg(Rag2-Igb)1Mnz/0	involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi
cx7	Cd79b^tm1Mnz/Cd79b^tm1Mnz Tg(BCL2)22Wehi/0 Tg(Rag2-Igb)1Mnz/0	involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi
cx8	Rad50^tm2Jpt/Rad50^tm2Jpt Tg(BCL2)22Wehi/0	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi
cx9	Tg(BCL2)22Wehi/0 Tg(IghMyc)22Bri/0	involves: C57BL/6 * C57BL/6JWehi * SJL/J * SJL/JWehi
cx10	Fnip1^tm1.2Baba/Fnip1^tm1.2Baba Tg(BCL2)22Wehi/0	involves: C57BL/6 * FVB/N * SJL
cx11	Atp11c^m1Btlr/Y Tg(BCL2)22Wehi/0	involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi
cx12	Igh-J^tm1.1Lave/Igh-J^tm1.1Lave Igk-J^tm1.1Lave/Igk-J^tm1.1Lave Tg(BCL2)22Wehi/0	involves: C57BL/6JWehi * SJL/JWehi
cx13	Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass Tg(BCL2)22Wehi/0	involves: C57BL/6 * SJL
tg14	Tg(BCL2)22Wehi/0	involves: C57BL/6J * C57BL/6JWehi
tg15	Tg(BCL2)22Wehi/0	involves: C57BL/6JWehi * SJL/JWehi

Phenotypes:

Affected Systems	cn1	cn2	cx3	cx4	cx5	cx6	cx7	cx8	cx9	cx10	cx11	cx12	cx13	tg14	tg15
show or hide all annotated terms Sex:
endocrine/exocrine glands									√
enlarged thymus									√
growth/size/body	√								√
enlarged spleen	√								√
hematopoietic system	√	√	√		√	√	√	√	√	√	√	√		√	√
enlarged thymus									√
enlarged spleen	√								√
anemia								√
increased leukocyte cell number									√
abnormal B cell morphology									√
abnormal B cell differentiation												√			√
abnormal plasma cell differentiation	√
arrested B cell differentiation						√	√
decreased B cell number		√									√
decreased mature B cell number		√	√								√
decreased follicular B cell number											√
increased B cell number					√				√	√				√	√
increased immature B cell number			√
increased marginal zone B cell number											√
abnormal pre-B cell morphology									√
increased pre-B cell number									√
abnormal B cell physiology	√		√												√
homeostasis/metabolism													√
abnormal enzyme/coenzyme activity													√
immune system	√	√	√	√	√	√	√		√	√	√	√	N	√	√
immune system phenotype													N
enlarged thymus									√
enlarged spleen	√								√
increased leukocyte cell number									√
abnormal B cell morphology									√
abnormal B cell differentiation												√			√
abnormal plasma cell differentiation	√
arrested B cell differentiation						√	√
decreased B cell number		√									√
decreased mature B cell number		√	√								√
decreased follicular B cell number											√
increased B cell number					√				√	√				√	√
increased immature B cell number			√
increased marginal zone B cell number											√
abnormal pre-B cell morphology									√
increased pre-B cell number									√
abnormal B cell physiology	√		√												√
enlarged lymph nodes	√								√
increased susceptibility to autoimmune disorder															√
increased anti-double stranded DNA antibody level				√
mortality/aging								√	√
premature death								√	√
neoplasm									√
increased lymphoma incidence									√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

In transgenic mice on a C57BL/6 background, expression of the transgene is restricted to the B cell lineage (no T-cell expression).

References

• Original: J:93111 Strasser A, et al., Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice. Curr Top Microbiol Immunol. 1990;166:175-81
• All: 94 reference(s)