Tbxas1^tm1Swl
Targeted Allele Detail

Summary

• Symbol: Tbxas1^tm1Swl
• Name: thromboxane A synthase 1, platelet; targeted mutation 1, Shu-Wha Lin
• MGI ID: MGI:3052866
• Synonyms: TXAS^-
• Gene: Tbxas1 Location: Chr6:38852338-39061519 bp, + strand Genetic Position: Chr6, 17.85 cM, cytoband F1-pter
• Alliance: Tbxas1^tm1Swl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90922
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding amino acids 234-333 and the first 233 bp of intron 9 were replaced with an HPRT cassette. Southern blot and PCR using tail DNA confirmed recombination. Northern blot and RT-PCR showed lack of wild-type transcript in spleen and thymus tissues of mutants. (J:90922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbxas1 Mutation: 30 strains or lines available

References

• Original: J:90922 Yu IS, et al., TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death. Blood. 2004 Jul 1;104(1):135-42
• All: 2 reference(s)