Sema4a^{Gt(OST393408)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Sema4a^{Gt(OST393408)Lex}
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; gene trap OST393408, Lexicon Genetics
• MGI ID: MGI:3052925
• Synonyms: Sema4a^Gt22Lex
• Gene: Sema4a Location: Chr3:88343266-88368489 bp, - strand Genetic Position: Chr3, 38.83 cM
• Alliance: Sema4a^{Gt(OST393408)Lex} page

Mutation origin

• Mutant Cell Line: OST393408
• Germline Transmission: Earliest citation of germline transmission: J:92305
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector consisting of LTR sites and a Neo marker was inserted into intron 11 of the endogenous gene. RT-PCR analysis detected no endogenous transcript in the eyes of homozygous mice. (J:92305)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST393408	CG646708 ; (MGI Seq Detail)	3' RACE	Chr3:88344495-88345862 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sema4a Mutation: 39 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:92305 Rice DS, et al., Severe retinal degeneration associated with disruption of semaphorin 4A. Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2767-77
• All: 3 reference(s)